Although it is a front-line in tuberculosis treatment. rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity. Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks. A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios. https://www.mamapaisa.com/product-category/hold-spray/