Drug hypersensitivity (DH) reactions are clinically unusual because the underlying immune stimulations are not antigen-driven. but due to non-covalent drug-protein binding. The drugs may bind to immune receptors like HLA or TCR which elicits a strong T cell reaction (p-i concept). the binding may enhance the affinity of antibodies (enhanced affinity model). https://thebrickes.shop/product-category/christmas-tree/