Because developing causation via experimental trials was impossible because of moral restrictions, a lengthy review was conducted to be able to determine the solid association necessary to allow for for legislative action from cigarette smoking tobacco.[citation desired] In cigarette smoking, long-term exposure to compounds located in the smoke (e.g., https://damienlewnd.wikigiogio.com/1363780/how_tabacco_can_save_you_time_stress_and_money